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KMID : 0352720150390010029
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Journal of Ginseng Research
2015 Volume.39 No. 1 p.29 ~ p.37
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Ginsenoside fractions regulate the action of monocytes and their differentiation into dendritic cells
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Lee Yeo-Jin
Son Young-Min
Gu Min-Jeong
Song Ki-Duk
Park Sung-Moo
Song Hyo-Jin
Kang Jae-Sung
Woo Jong-Soo
Jung Jee-Hyung
Yang Deok-Chun
Han Seung-Hyun
Yun Cheol-Heui
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Abstract
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blood mononuclear cells (PBMCs) and on their differentiation into DCs that affect CD4+ T cell activity. Results: After treatment with ginsenoside fractions, monocyte levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-10 increased through phosphorylation of extracellular signal-regulated kinase (ERK)1/2 and c-Jun N-terminal kinase (JNK), but not p38 mitogen-activated protein kinase (MAPK). After treatment with ginsenoside fractions, TNF-α production and phosphorylation of ERK1/2 and JNK decreased in lipopolysaccharide (LPS)-sensitized monocytes.We confirmed that DCs derived from CD14+ monocytes in the presence of ginsenoside fractions (Gin-DCs) contained decreased levels of the costimulatory molecules CD80 and CD86. The expression of these costimulatory molecules decreased in LPS-treated DCs exposed to ginsenoside fractions, compared to their expression in LPS-treated DCs in the absence of ginsenoside fractions. Furthermore, LPS-treated Gin-DCs could not induce proliferation and interferon gamma (IFN-γ) production by CD4+ T cells with the coculture of Gin-DCs with CD4+ T cells. Conclusion: These results suggest that ginsenoside fractions from the ginseng root suppress cytokine production and maturation of LPS-treated DCs and downregulate CD4+ T cells.
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KEYWORD
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CD14+ monocytes, CD14+ T cells, dendritic cells, ginsenosides, Panax ginseng
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